National Poisons Information Service

A service commissioned by Public Health England

 

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Members of the public

seeking specific

information on poisons

should contact:

 

In England and Wales:

NHS 111 - dial 111

 

In Scotland:

NHS 24 - dial 111

 

In N Ireland:

Contact your local GP or

pharmacist during

normal hours; click here

(www.gpoutofhours

.hscni.net/) for GP

services Out-of-Hours.

 

In Republic of Ireland:

01 809 2166

 

Healthcare

professionals seeking

poisons information

should consult:

www.toxbase.org

NPIS publications - papers

Acheampong P, Cooper G, Khazaeli B, Lupton DJ, White S, May MT, Thomas SHL. Effects of MHRA drug safety advice on time trends in prescribing volume and indices of clinical toxicity for quinine. Br J Clin Pharmacol 2013; 76: 973–9.

 

Acheampong P, Thomas SHL. Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion; systematic review of reported cases. Br J Clin Pharmacol 2016; 82: 923-31.

 

Al-Hourani K, Mansi R, Pettie J, Dow M, Bateman DN, Dear JW. The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose. QJM 2013; 106: 541–6.

 

Aldeyab MA, Noble SC, Cuthbert M, Maxwell S, Dear J, Boyter A. Assessment of the impact of the Scottish public health campaign on patient reporting of adverse drug reactions. Drug Ther Perspect 2016; 32: 209-18.

 

Anderson M. The management of poisoning. Paediatr Child Health 2013; 23: 380–84.

 

Anderson M, Hawkins L, Eddleston M, Thompson JP, Vale JA, Thomas SH. Severe and fatal pharmaceutical poisoning in young children in the UK. Arch Dis Child 2016; 101: 653-6.

 

Antoine DJ, Dear JW, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 2013; 58: 777–87.

 

Antoine DJ, Dear JW. How to treat paracetamol overdose and when to do it. Expert Rev Clin Pharmacol 2016; 9: 633-5. 

 

Antoine DJ, Dear JW. Transformative biomarkers for drug-induced liver injury: are we there yet? Biomark Med 2017. Published online 18/1/17.

 

Antoine DJ, Sabbisetti VS, Francis B, Jorgensen AL, Craig DG, Simpson KJ, Bonventre JV, Park BK, Dear JW. Circulating kidney injury molecule 1 predicts prognosis and poor outcome in patients with acetaminophen-induced liver injury. Hepatol 2015; 62: 591-9.

 

Bailey GP, Najafi J, Elamin ME, Waring WS, Thomas SH, Archer JR, Wood DM, Dargan PI. Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. Br J Clin Pharmacol 2016; 82: 1358-63.

 

Bailey GP, Rehman B, Wind K, Wood DM, Thanacoody R, Bash S, Archer JRH, Eddleston M, Thompson JP, Vale JA, Thomas SHL, Dargan PI. Taking stock: UK national antidote availability increasing, but further improvements are required. Eur J Hosp Pharm 2015; 23: 145-50.

 

Balmforth C, van Bragt JJMH, Ruijs T, Cameron J, Kimmitt RA, Moorhouse R, Czopek A, Hu MK, Gallacher PJ, Dear JW, Borooah S, MacIntyre IM, Pearson TMC, Willox L, Talwar D, Tafflet M, Roubeix C, Sennlaub F, Chandran S, Dhillon B, Webb DJ, Dhaun N. Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction. JCI Insight 2016. Published online 8/12/16.

 

Bateman DN, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Cranfield KR, Hook C, Sandilands EA, Veiraiah A, Webb D, Gray A, Dargan PI, Wood DM, Thomas SHL, Dear JW, Eddleston M. Effect of the UK’s revised paracetamol poisoning management guidelines on admissions, adverse reactions, and costs of treatment. Br J Clin Pharm 2014; 78: 610–18. 

 

Bateman DN, Dear JW. Should we treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017. Published online 2/3/17.

 

Bateman DN, Dear JW, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Gray A, Dargan PI, Wood DM, Eddleston M, Thomas SH. Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning. The recent United Kingdom experience. Clin Toxicol 2014; 52: 868–72. 

 

Bateman DN, Dear JW, Thanacoody HK, Thomas SHL, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart AD, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet 2014; 383: 697–704. 

 

Bateman DN, Dear JW, Thanacoody HKR, Thomas SHL, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vligenthaart ADB, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomized controlled trial. Lancet 2014; 383: 697–704.

 

Bateman DN, Dear JW, Thomas SHL. New regimens for intravenous acetylcysteine, where are we now? Clin Toxicol 2016; 54: 75-8.

 

Bateman DN, Dear JW. Limitations of AST/ALT ratio in paracetamol poisoning. Clin Toxicol 2015; 53: 580.

 

Bateman DN, Vale A. Paracetamol (acetaminophen). Medicine 2016; 44: 190-2.

 

Bradberry S, Vale A. Management of poisoning: antidotes. Medicine 2016; 44: 101-2. 

 

Bradberry S, Vale A. Plants. Medicine 2016; 44: 113-15.

 

Bradberry S, Vale A. Warfarin and anticoagulant rodenticides. Medicine 2016; 44: 201. 

 

Bradberry S. Acetone. Medicine 2016; 44: 127. 

 

Bradberry S. Lithium. Medicine 2016; 44: 180-1. 

 

Bradberry S. Methaemoglobinaemia. Medicine 2016; 44: 91-2. 

 

Bradberry S. Ricin and abrin. Medicine 2016; 44: 109-10.

 

Bradberry SM, Wilkinson JM, Ferner RE. Systemic toxicity related to metal hip prostheses. Clin Toxicol 2014; 52: 837–47. 

 

Bradberry SM. Metals (cobalt, copper, lead, mercury). Medicine 2016; 44: 182-4.

 

Cairney DG, Beckwith HKS, Al-Hourani K, Eddleston M, Bateman DN, Dear J. Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. Clin Toxicol 2016; 54: 405-10.

 

Charlton RA, McGrogan A, Snowball J, Yates L, Wood A, Clayton-Smith J, Smithson WH, Richardson J, McHugh N, Thomas SHL, Baker GA, Bromley R. Sensitivity of the UK Clinical Practice Research Datalink to detect neurodevelopmental effects of medicine exposure in utero: a comparative analysis of an antiepileptic drug exposed cohort. Drug Safety. Published online 10/2/17.

 

Clarke JI, Dear JW, Antoine DJ. Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon? Expert Opin Drug Saf 2016; 15: 625-34.

 

Coulson JM, Caparrotta TM, Thompson JP. The management of ventricular dysrhythmia in aconite poisoning. Clin Toxicol 2017. Published online 20/2/17.

 

Coulson JM, Cooper G, Krishna C, Thompson JP. Snakebite enquiries to the UK National Poisons Information Service: 2004–2010. Emerg Med J 2013; 30: 932–4.

 

Coulson JM, Murphy K, Harris AD, Fjodorova M, Cockcroft JR, Wise RG. Correlation between baseline blood pressure and the brainstem FMRI response to isometric forearm contraction in human volunteers: a pilot study. J Hum Hypertens 2015; 29: 449-55.

 

Coulson JM. The efficacy of pralidoxime in organophosphorus poisoning: A commentary. J Postgrad Med 2014; 60: 31–2.

 

Coulson JM. The relationship between blood pressure variability and catecholamine metabolites: a pilot study. J Hum Hypertens 2015; 29: 50–52. 

 

Crawford C, Anderson M, Cooper G, Jackson G, Thompson J, Vale A, Thomas S, Eddleston M, Bateman DN. Overdose in young children treated with anti-reflux medications: Poisons enquiry evidence of excess 10-fold dosing errors with ranitidine. Hum Exp Toxicol 2017. Published online 1/1/17.

 

Day R, Eddleston M, Thomas SHL, Thompson JP, Bradberry SM, Vale JA. Toxicity from automotive screenwashes reported to the United Kingdom National Poisons Information Service (NPIS) from 2012 to 2015. Clin Toxicol 2017; 55: 221–226.

 

Day R, Eddleston M, Thomas SHL, Thompson JP, Vale JA. Exposures to traditional automatic dishwashing tablets and a comparison with exposures to soluble film tablets reported to the United Kingdom National Poisons Information Service 2008-2015. Clin Toxicol 2017; 55: 206–212.

 

Day R, Eddleston M, Thomas SHL, Thompson JP, Vale JA. The impact of an international initiative on exposures to liquid laundry detergent capsules reported to the United Kingdom National Poisons Information Service between 2008 and 2015. Clin Toxicol 2017; 55: 213–216.

 

Day R, Eddleston M, Thomas SHL, Thompson JP, Vale JA. Toxicity of soluble film automatic dishwashing products as reported to the United Kingdom National Poisons Information Service 2008–2015. Clin Toxicol 2016; 54: 862–866.

 

Dear JW, Antoine DJ, Park BK. Where are we now with paracetamol? BMJ 2015; 351: h3705. 

 

Dear JW, Antoine DJ. Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. Expert Rev Clin Pharmacol 2014; 7: 181–9.

 

Dear JW, Bateman DN. Antidepressants. Medicine 2016; 44: 135-7.

 

Dear JW, Bateman DN. Antipsychotic drugs. Medicine 2016; 44: 143-4.

 

Dear JW, Bateman DN. Benzodiazepines. Medicine 2016; 44: 145.

 

Dear JW, Bateman DN. Iron. Medicine 2016; 44: 173-4.

 

Dear JW, Street JM, Bailey MA. Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling. Proteomics 2013; 13: 1572–80. Review.

 

Dear JW. Urinary exosomes join the fight against infection. J Am Soc Nephrol 2014; 25: 1889–91. 

 

Doris MK, Sandilands EA. Life-threatening opioid toxicity from a fentanyl patch applied to eczematous skin. BMJ Case Rep 2015; published online 29 April 2015.

 

Dreyer NA, Blackburn S, Hliva V, Mt-Isa S, Richardson J, Jamry-Dziurla A, Bourke A, Johnson R. Balancing the interests of patient data protection and medication safety monitoring in a public-private partnership. JMIR Med Inform 2015; 15; e18.

 

Dreyer NA, Blackburn SC, Mt-Isa S, Richardson JL, Thomas S, Laursen M, Zetstra-van der Woude P, Jamry-Dziurla A, Hliva V, Bourke A, de Jong-van den Berg L. Direct-to-patient research: piloting a new approach to understanding drug safety during pregnancy. JMIR Public Health Surveill 2015; 1: e22. 

 

Dunstan HJ, Mill AC, Stephens S, Yates LM, Thomas SHL. Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A/H1N1 pandemic: a national prospective surveillance study. Br J Obstet Gynae 2014; published online 7 Mar 2014 (121(7): 901–6).

 

Dunstan HJ, Richardson JL, Greenall AJ, Jones D, Stephens S, Yates LM, Thomas SHL. First trimester exposure to aripiprazole and the risk of congenital malformations; a case series. Reproductive Toxicol 2015; 57: 217.

 

Eddleston M, Thomas SHL, Thompson JP, Vale JA. Response to Arkell et al, regarding TOXBASE guidance. Emerg Med J 2013; published online 20 June 2013.

 

Eddleston M. Applied clinical pharmacology and public health in rural Asia – preventing deaths from organophosphorus pesticide and yellow oleander poisoning. Br J Clin Pharmacol 2013; 75: 1175–88.

 

Eddleston M. Pesticides. Medicine 2016; 44: 193-6.

 

Eddleston M. Progress with reducing mortality from organophosphorus insecticide poisoning. Anuradhapura Med J 2014, 8: 1–4.

 

Fujii H, Goel A, Bernard N, Pistelli A, Yates LM, Stephens S, Han JY, Matsui D, Etwell F, Einarson TR, Koren G, Einarson A. Pregnancy outcomes following gabapentin use: results of a prospective comparative cohort study. Neurology 2013; 80: 1565–70.

 

Gosselin S, Hoegberg LC, Hoffman RS, Graudins A, Stork CM, Thomas SH, Stellpflug SJ, Hayes BD, Levine M, Morris M, Nesbitt-Miller A, Turgeon AF, Bailey B, Calello DP, Chuang R, Bania TC, Mégarbane B, Bhalla A, Lavergne V. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol 2016; 54: 899-923.

 

Gosselin S, Morris M, Miller-Nesbitt A, Hoffman RS, Hayes BD, Turgeon AF, Gilfix BM, Grunbaum AM, Bania TC, Thomas SH, Morais JA, Graudins A, Bailey B, Mégarbane B, Calello DP, Levine M, Stellpflug SJ, Hoegberg LC, Chuang R, Stork C, Bhalla A, Rollins CJ, Lavergne V; AACT Lipid Emulsion Therapy workgroup. Methodology for AACT evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol 2015; 6; 557-64.

 

Gray L, Tuthill DP, Thompson J. Management of drug allergy. Paediatr Child Health 2014; 24: 177–9.

 

Hazell L, Raschi E, De Ponti F, Thomas SHL, Salvo F, Helgee AH, Boyer S, Miriam Sturkenboom M, Shakir S. Evidence for the hERG liability of antihistamines, antipsychotics and anti-infective agents: a systematic literature review from the ARITMO project. J Clin Pharmacol 2016. Published online 26/12/16.

 

Henke D, Campbell A, Bradberry SM, Sandilands EA, Thomas SHL, Thompson JP, Vale JA. Toxicity from fluoropolymer-containing grout, tile and stone floor sealants reported to the UK National Poisons Information Service 2009–2015. Clin Toxicol 2017. Published online 28/3/17.

 

Hill S, Thomas SH. Drugs of abuse. Medicine 2016; 44: 160-9.

 

Hill SL, Doris T, Gurung S, Katebe S, Lomas A, Dunn M, Blain P, Thomas SHL. Severe clinical toxicity associated with analytically confirmed recreational use of 25I-NBOMe: case series. Clin Toxicol 2013; 51: 487–92.

 

Hill SL, Harbon S, Coulson J, Thompson J, Jackson G, Lupton DJ, Eddleston M, Vale A, Thomas SH. Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK’s first temporary class drug order). Emerg Med J 2014; 31: 45–7.

 

Hill SL, Najafi J, Dunn M, Acheampong P, Kamour A, Grundlingh J, Blain PG, Thomas SHL. Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification of Novel Psychoactive Substances (IONA) study. Clin Toxicol 2016; 54: 638-43.

 

Hill SL, Thomas SHL, Flecknell PA, Thomas AA, Morris CM, Henderson D, Dunn M, Blain PG. Rapid and equivalent systemic bioavailability of the antidotes HI-6 and dicobalt edetate via the intraosseous and intravenous routes. Emerg Med J 2015; 32: 626-31.

 

Hoegberg LC, Bania TC, Lavergne V, Bailey B, Turgeon AF, Thomas SH, Morris M, Miller-Nesbitt A, Mégarbane B, Magder S, Gosselin S; Lipid Emulsion Workgroup. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol 2016; 54: 167-93.

 

Hornby RJ, Starkey Lewis P, Dear J, Goldring C, Park K. MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. Exp Rev Clin Pharmacol 2014; 7: 349–62. 

 

Hughes D, Routledge PA. A prescribing partnership. Pub Serv Rev: Health Social Care 2013; 35: 65–7.

 

Hulse E, Reed F, Eddleston M, Etherington R, Clutton E. Experiences with a bronchial blocking device for pulmonary aspiration studies in the Gottingen Minipig. Lab Anim 2014, 48: 164–9.

 

Hulse EJ, Davies JOJ, Simpson AJ, Sciuto A, Eddleston M. Respiratory complications of organo-phosphorus nerve agent and insecticide poisoning - implications for respiratory and critical care. Am J Resp Crit Care Med 2014; 190: 1342–54. 

 

Ivy J, Oosthuyzen W, Peltz TS, Howarth AR, Hunter RW, Dhaun N, Al-Dujaili EA, Webb DJ, Dear JW, Flatman PW, Bailey MA. Glucocorticoids induce nondipping blood pressure by activating the thiazide-sensitive cotransporter. Hypertension 2016; 67: 1039-37.

 

Kamour A, Crichton S, Cooper G, Lupton DJ, Eddleston M, Vale JA, Thompson JP, Thomas SH. Central nervous system toxicity of mefenamic acid overdose compared with other NSAIDs: an analysis of cases reported to the United Kingdom National Poisons Information Service. Br J Clin Pharmacol 2016; 83: 855-62.

 

Kamour A, George N, Gwynnette D, Cooper G, Lupton D, Eddleston M, Thompson JP, Vale JA, Thanacoody HKR, Hill S, Thomas SHL. Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service. Emerg Med J 2015; 32: 383-6.

 

Kamour A, George S, Vale JA. Prolonged tachycardia following analytically confirmed cyclizine ingestion. Clin Toxicol 2013; 51: 456–57.

 

Kamour A, James D, Lupton DJ, Cooper G, Eddleston M, Vale JA, Thompson JP, Thanacoody HKR, Hill SL, Thomas SHL. Patterns of presentation and clinical features of toxicity after reported use of ([2-aminopropyl]-2,3-dihydrobenzofurans), the ‘benzofuran’ compounds. A report from the United Kingdom National Poisons Information Service. Clin Toxicol 2014; 52: 1025–31. 

 

Kamour A, James D, Spears R, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale AJ, Thanacoody HK, Hill SL, Thomas SH. Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom. A report from the UK National Poisons Information Service. Clin Toxicol 2014; 52: 192–7.

 

Knipe DW, Metcalfe C, Fernando R, Pearson M, Konradsen F, Eddleston M, Gunnell D. Suicide in Sri Lanka 1975-2012: age, period and cohort analysis of police and hospital data. BMC Public Health 2014;14: 839. 

 

Konickx LA, Bingham K, Eddleston M. Is oxygen required before atropine administration in organo-phosphorus or carbamate pesticide poisoning? – a cohort study. Clin Toxicol 2014; 52: 531–7. 

 

Lazo JS, Routledge PA. International collaboration, a vital component of scientific progress. Pharmacologist 2013; 55: 30, and Pharmacol Matt 2013; 6: 5.

 

Li B, Eyer P, Eddleston M, Jiang W, Schopfer LM, Lockridge O. Protein tyrosine adduct in humans self-poisoned by chlorpyrifos. Toxicol Appl Pharmacol 2013; 269: 215–25.

 

Liga A, Vliegenthart AD, Oosthuyzen W, Dear JW, Kersaudy-Kerhoas M. Exosome isolation: a microfluidic road-map. Lab Chip 2015; 15: 2388-94. 

 

Marrs TC, Thompson JP. The efficacy and adverse effects of dicobalt edetate in cyanide poisoning. Clin Toxicol 2016; 54: 609-14.

 

McCloskey S, Yates LM, Sayer JA. The importance of taking a family history in the nephrology clinic. Br J Renal Med 2016; 21; 38-41.

 

McCrae JC, Sharkey N, Webb DJ, Vliegenthart AD, Dear JW. Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals. Clin Toxicol 2016; 54: 53-5. 

 

Menzies RI, Zammit-Mangion A, Hollis LM, Lennen RJ, Jansen MA, Webb DJ, Mullins JJ, Dear JW, Sanguinetti G, Bailey MA. An anatomically unbiased approach for analysis of renal BOLD magnetic resonance images. Am J Physiol Renal Physiol 2013; 305: F845–52.

 

Morrison EE, Bailey MA, Dear JW. Renal extracellular vesicles: from physiology to clinical application. J Physiol 2016; 594: 5735-48.

 

Morrison EE, Dear JW, Sandilands EA. Self-poisoning in the elderly: A 10-year observational study. Clin Toxicol 2015; 53: 404-7.

 

Narayan H, Thomas SHL, Eddleston M, Dear JW, Sandilands E, Bateman DN. Disproportionate effect on child admissions of the change in MHRA guidance for management of paracetamol poisoning. Br J Clin Pharmacol 2015; 80: 1458-63. 

 

Newham R , Corcoran ED, Dear JW, Hems S, McTaggart S,Bennie M (2015). A qualitative study of the relationship between the Scottish Medicines Consortium and their clinical experts. J Eval Clin Prac 2015. Published online 23/3/15. 

 

O'Connell C, Amar D, Boucly A, Savale L, Jaïs X, Chaumais M-C, Montani D, Humbert M, Simonneau G, Sitbon O. Comparative safety and tolerability of prostacyclins in pulmonary hypertension. Drug Saf 2016; 39: 287–294.

 

O'Donnell A, McParlin C, Robson S, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead C, Nelson-Piercy C, Newbury-Birch D, Norman J, Simpson E, Swallow B, Yates L, Vale L. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review. JAMA 2016; 316: 1392-1401.

 

O'Donnell A, McParlin C, Robson S, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead C, Nelson-Piercy C, Newbury-Birch D, Norman J, Simpson E, Swallow B, Yates L, Vale L. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment. Health Tech Assess 2016; 20: 1-268.

 

Oosthuyzen W, Scullion KM, Ivy J, Morrison E, Hunter RW, Starkey Lewis PJ, O’Duibhir E, Street JM, Caporali A, Gregory CD, Forbes SJ, Webb DJ, Bailey MA, Dear JW. Vasopressin regulates extracellular vesicle uptake by kidney collecting duct cells. J Am Soc Nephrol 2016; 27: 3345-55.

 

Oosthuyzen W, Sime NE, Ivy JR, Turtle EJ, Street JM, Pound J, Bath LE, Webb DJ, Gregory CD, Bailey MA, Dear JW. Quantification of human urinary exosomes by nanoparticle tracking analysis. J Physiol 2013; 591: 5833–42.

 

Panchal B, Eddleston M, Thomas SH, Thompson JP, Vale JA. 754 exposures to reed diffusers reported to the United Kingdom National Poisons Information Service 2010-2014. Clin Toxicol 2016; 54: 333-8.

 

Park BK, Dear JW, Antoine DJ. Paracetamol (acetaminophen) poisoning. BMJ Clin Evid 2015; pii: 2101.

 

Parkinson K, Newbury-Birch D, Phillipson A, Hindmarch P, Kaner E, Stamp E, Vale L, Wright J, Connolly J. Prevalence of alcohol related attendance at an inner city emergency department and its impact: a dual prospective and retrospective cohort study. J Accid Emerg Med 2001 2016; 33: 187–193.

 

Perry L, Adams RD, Bennett A, Lupton DJ, Jackson G, Good AM, Thomas SH, Vale JA, Thompson J, Bateman DN, Eddleston M. National toxicovigilance for pesticide exposures resulting in healthcare contact – an example from the UK’s National Poisons Information Service. Clin Toxicol 2014; 52: 549–55. 

 

Proudfoot AT, Good AM, Bateman DN. Clinical toxicology in Edinburgh, two centuries of progress. Clin Toxicol 2013; 51: 509–14.

 

Ramasubbu B, James D, Scurr A, Sandilands EA. Serum alkalinisation is the cornerstone of treatment for amitriptyline poisoning. BMJ Case Reports 2016. Published online 11/4/16.

 

Rehman B, Wind K, Wood DM, Thanacoody R, Bailey GP, Nash S, Archer JRH, Eddleston M, Thompson JP, Vale JA, Thomas SHL, Dargan PI. Taking stock: UK national antidote availability increasing, but further improvements are required. Eur J Hosp Pharmacy 2016; 23: 145-50.

 

Richardson JL, Stephens S, Thomas SH, Jamry-Dziurla A, de Jong-van den Berg L, Zetstra-van der Woude P, Laursen M, Hliva V, Mt-Isa S, Bourke A, Dreyer NA, Blackburn SC. An international study of the ability and cost-effectiveness of advertising methods to facilitate study participant self-enrolment into a pilot pharmacovigilance study during early pregnancy. JMIR Public Health Surveill 2016; 18: e13. 

 

Richardson JL, Stephens S, Yates LM, Diav-Citrin O, Arnon J, Beghin D, Kayser A, Kennedy D, Cupitt D, Te Winkel B, Peltonen M, Kaplan YC, Thomas SH. Pregnancy outcomes after maternal varenicline use; analysis of surveillance data collected by the European Network of Teratology Information Services. Reprod Toxicol 2017; 67: 26-34.

 

Richardson JL, Stephens S, Yates LM, Thomas SH. Gestational antidepressant use and the risk of spontaneous abortion. Reproductive Toxicol 2015; 57: 211.

 

Rivoli L, Vliegenthart B, de Potter C, van Bragt J, Tzoumas N, Gallacher P, Farrah TE, Dhaun N, Dear JW. The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122. Br J Clin Pharmacol 2016. Published online 21/10/16.

 

Roberts L, Ford L, Patel N, Vale JA, Bradberry SM. 11 analytically confirmed cases of mexedrone use among polydrug users. Clin Toxicol 2017; 55: 181–186.

 

Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A. Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park BK, Betensky R, Krolewski AS, Bonventre JV. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol 2014; 25: 2177–86. 

 

Salvo F, Pariente A, Shakir S, Robinson P, Arnaud M, Thomas SH, Raschi E, Fourrier-Réglat A, Moore N, Sturkenboom M, Hazell L; Investigators of the ARITMO consortium. Sudden cardiac and sudden unexpected death related to antipsychotics: A meta-analysis of observational studies. Clin Pharmacol Ther 2016; 99: 306-14.

 

Sandilands E, Crowe J, Cuthbert H, Jenkins PJ, Johnston NR, Eddleston M, Bateman DN, Webb DJ. Histamine-induced vasodilatation in the human forearm vasculature. Br J Clin Pharmacol 2013, 76: 699–707.

 

Sandilands EA, Bateman DN. Carbon monoxide. Medicine 2016; 44: 151-2.

 

Sandilands EA, Bateman DN. Non-steroidal anti-inflammatory drugs. Medicine 2016; 44: 185-6.

 

Sandilands EA, Bateman DN. Opioids. Medicine 2016; 44: 187-9.

 

Sandilands EA, Bateman DN. The epidemiology of poisoning. Medicine 2016; 44: 76-9.

 

Sandilands EA, Dhaun N, Dear JW, Webb DJ. Measurement of renal function in patients with chronic kidney disease. Br J Clin Pharmacol 2013; 76: 504–15.

 

Schep LJ, Slaughter RJ, Vale JA, Wheatley P. Was the death of Alexander the Great due to poisoning? Was it Veratrum album? Clin Toxicol 2014; 52: 72–77.

 

Slaughter RJ, Mason RW, Beasley DMG, Vale JA, Schep LJ. Isopropanol poisoning. Clin Toxicol 2014; 52: 470–78. 

 

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ. CSF1 Restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterol 2015; 149: 1896-1909.

 

Tait RJ, Caldicott D, Mountain D, Hill SL, Lenton S. A systematic review of adverse effects arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol 2016; 54: 1-13.

 

Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol 2013; 14: 20.

 

Thanacoody HKR, Aldridge G, Laing W, Nash S, Dargan PI, Vale JA, Bateman DN, Thompson JP, Thomas SHL. National audit of antidote stocking in acute hospitals in the United Kingdom. Emerg Med J 2013; 30: 393–6.

 

Thanacoody HKR. Quinine and chloroquine. Medicine 2016; 44: 197-8.

 

Thanacoody HKR. Serotonin syndrome. Medicine 2016; 44: 95-6.

 

Thanacoody R, Caravati EM, Troutman WG, Höjer J, Benson BE, Hoppu K, Erdman A, Bedry R, Mégarbane B. Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Clin Toxicol 2015: 53: 5-12.

 

Thanacoody RHK, Gilfillan C, Bradberry SM, Davies J, Jackson G, Vale JA, Thompson JP, Eddleston M, Thomas SHL. Management of poisoning with ethylene glycol and methanol in the UK: a prospective study conducted by the National Poisons Information Service (NPIS). Clin Toxicol 2016; 54: 134-40.

 

Thomas SHL, Behr ER. Pharmacological treatment of acquired QT prolongation and torsades de pointes. Br J Clin Pharmacol 2016; 81: 420-7.

 

Thomas SHL. Antihistamine poisoning. Medicine 2016; 44: 141-2.

 

Thomas SHL. Is the cause toxicological? Medicine 2016; 44: 80-1.

 

Thompson J, Watson I, Thanacoody H, Morley S, Thomas S, Eddleston M, Vale J, Bateman D, Krishna C. Guidelines for laboratory analyses for poisoned patients in the United Kingdom. Ann Clin Biochem 2014; published online 29 January 2014 (51(Part 3): 312–25).

 

Turtle EJ, Dear JW, Webb DJ. A systematic review of the effect of paracetamol on blood pressure in hypertensive and non- hypertensive subjects. Br J Clin Pharmacol 2013; 75: 1396–405. Review.

 

Vale A, Bradberry S. Assessment and diagnosis of the poisoned patient. Medicine 2016; 44: 82-6.

 

Vale A, Bradberry S. Management of poisoning. Medicine 2013; 41: 179–81.5.

 

Vale A, Bradberry S. Management of poisoning: initial management. Medicine GBR 2016; 44: 97-8.

 

Vale A, Bradberry S. Poisoning: introduction. Medicine 2016; 44: 75. 

 

Vale A, Lotti M. Organophosphorus and carbamate insecticide poisoning. Handb Clin Neurol 2015; 131: 149-68.

 

Vale A, Marrs TC, Rice P. Chemical terrorism and nerve agents. Medicine 2016; 44: 106-8.

 

Vale A. Alcohols and glycols. Medicine 2016; 44: 128-32.

 

Vale A. Anticonvulsants. Medicine 2016; 44: 133-4.

 

Vale A. Cyanide. Medicine 2016; 44: 157.

 

Vale A. Household products. Medicine 2016; 44: 170-2.

 

Vale A. Isopropanol. Medicine 2016; 44: 179.

 

Vale A. Organophosphorus insecticide poisoning. BMJ Clinical Evidence 2015. Published online 30/11/15.

 

Vale A. Reducing absorption and increasing elimination. Medicine 2016; 44: 99-100.

 

Vale A. Rhabdomyolysis. Medicine 2016; 44: 93-4.

 

Vale A. Salicylates. Medicine 2016; 44: 199-200.

 

Vale A. ß2-agonists. Medicine 2016; 44: 146.

 

Vale A. ß-blockers. Medicine 2016; 44: 147.

 

van Eijkeren JCH, Olie JDN, Bradberry SM, Vale JA, de Vries I, Clewell HJ III, Meulenbelt J, Hunault CC. Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead. Clin Toxicol 2017; 55: 133–141.

 

van Eijkeren JCH, Olie JD, Bradberry SM, Vale JA, de Vries I, Meulenbelt J, Hunault CC. Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans. Clin Toxicol 2016; 54: 833–839.

 

Vliegenthart AD, Antoine DJ, Dear JW. Target biomarker profile for the clinical management of paracetamol overdose. Br J Clin Pharmacol 2015; 80: 351-62. 

 

Vliegenthart ADB, Berends C, Potter CMJ, Kersaudy-Kerhoas M, Dear JW. MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury. Br J Clin Pharmacol 2017. Published online 3/3/17.

 

Vliegenthart B, Kimmitt RA, Seymour JH, Homer N, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW. Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury. Clin Pharmacol Ther 2016. Published online 30/11/16.

 

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW. Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Sci Rep 2015; 5: 15501. 

 

Vliegenthart AD, Starkey Lewis P, Tucker CS, Del Pozo J, Rider S, Antoine DJ, Dubost V, Westphal M, Moulin P, Bailey MA, Moggs JG, Goldring CE, Park BK, Dear JW. Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish 2014; published online 13 March 2014 (11(3): 219–26).

 

Vliegenthart ADB, Tucker CS, Del Pozo J, Dear JW. Zebrafish as model organisms for studying drug induced liver injury. Br J Clin Pharmacol 2014; 78: 1217–27. 

 

Waugh J, Najafi J, Hawkins L, Hill SL, Eddleston M, Vale JA, Thompson JP, Thomas SHL. Epidemiology and clinical features of toxicity following recreational use of synthetic cannabinoid receptor agonists: a report from the United Kingdom National Poisons Information Service. Clin Toxicol 2016; 54: 512–518.

 

Weber-Schoendorfer C, Oppermann M, Wacker E, Bernard N; network of French pharmacovigilance centres, Beghin D, Cuppers-Maarschalkerweerd B, Richardson JL, Rothuizen LE, Pistelli A, Malm H, Eleftheriou G, Kennedy D, Kadioglu Duman M, Meister R, Schaefer C. Pregnancy outcome after TNF-α inhibitor therapy during the first trimester: a prospective multicentre cohort study. Br J Clin Pharmacol 2015; 80: 727-39.

 

Weerasinghe M, Pearson M, Peiris R, Dawson AH, Eddleston M, Jayamanne S, Konradsen F. The role of private pesticide vendors in preventing access to pesticides for self-poisoning in rural Sri Lanka. Inj Prev 2014, 20: 134–7.

 

Williams H, Jones S, Wood K, Scott RA, Eddleston M, Thomas SH, Thompson JP, Vale JA. Reported toxicity in 1486 liquid detergent capsule exposures to the UK National Poisons Information Service 2009–2012, including their ophthalmic and CNS effects. Clin Toxicol 2014; 52: 136–40.

 

Winterfeld U, Klinger G, Panchaud A, Stephens S, Arnon J, Malm H, Te Winkel B, Clementi M, Pistelli A, Maňáková E, Eleftheriou G, Merlob P, Kaplan YC, Buclin T, Rothuizen LE. Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study. J Clin Psychopharmacol 2015; 35: 250-9.

 

Winterfeld U, Merlob P, Baud D, Rousson V, Panchaud A, Rothuizen LE, Bernard N, Vial T, Yates LM, Pistelli A, Ellfolk M, Eleftheriou G, de Vries LC, Jonville-Bera AP, Kadioglu M, Biollaz J, Buclin T. Pregnancy outcome following maternal exposure to pregabalin may call for concern. Neurology 2016; 86: 2251-7.

 

Wood DM, Hill SL, Thomas SHL, Dargan PI. Using poisons information service data to assess the acute harms associated with novel psychoactive substances. Drug Test Anal 2014; 6: 850–860. 

 

Yates LM, Thomas SHL. Prescribing medicines in pregnancy. Medicine 2016; 44: 438-43.

 

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